Rabies Immune Globulin (Human) USP, Heat Treated Imogam® Rabies – HT

Although rabies among humans is rare in the US, every year approximately 16,000 to 39,000 persons receive postexposure prophylaxis.  In order to manage potential human exposures to rabies appropriately, the risk of infection must be accurately assessed. Administration of rabies postexposure prophylaxis is usually a medical urgency, not a medical emergency (facial and neck wounds are the exception), but decisions must not be delayed.

Systemic prophylactic treatments occasionally are complicated by adverse reactions, but these reactions are rarely severe.  Data on the safety, immunogenicity, and efficacy of active and passive rabies immunization have come from both human and animal studies. Although controlled human trials have not been performed, extensive field experience from many areas of the world indicates that postexposure prophylaxis combining aggressive local wound care, passive immunization, and vaccination is uniformly effective when appropriately applied.


Rabies Vaccine
(for Human Use) = Killed vaccine

Rabies is a viral infection transmitted via the saliva of infected mammals. The virus enters the central nervous system of the host (victim), causing an encephalomyelitis (brain/spinal cord infection) that is almost invariably fatal. The incubation period varies between 5 days and years, but is usually between 20 and 60 days. Clinical rabies presents either in a “furious” or in a “paralytic” form. Clinical illness most often starts with prodromal complaints of malaise, poor appetite, fatigue, headache, and fever, followed by pain or paresthesia (odd sensations) at the site of exposure. Anxiety, agitation, irritability may be prominent during this period, followed by hyperactivity, disorientation, seizures, aero- and hydrophobia, hypersalivation, and eventually paralysis, coma and death.

Modern day prophylaxis (preventive treatment) has proven nearly 100% successful; most human fatalities now occur in people who fail to seek medical treatment, usually because they do not recognize a risk in the animal contact leading to the infection or were unaware of any contact. Inappropriate postexposure prophylaxis may also result in clinical rabies. Survival after clinical rabies is extremely rare, and would probably be associated with severe brain damage and permanent disability.

RabAvert vaccine, in combination with passive immunization with Human Rabies Immune Globulin (HRIG) and aggressive local wound treatment in postexposure treatment against rabies has been shown to protect patients of all age groups from rabies, when the vaccine was administered according to the CDC’s Advisory Committee on Immunization Practices (ACIP) or World Health Organization (WHO) guidelines and as soon as possible after rabid animal contact. Anti-rabies antibody titers after immunization have been shown to reach levels well above the minimum antibody titer accepted as seroconversion (protective titer) within 14 days after initiating the postexposure treatment series.

Postexposure Treatment

No postexposure vaccine failures have occurred in the United States since cell culture vaccines have been routinely used. Failures have occurred abroad, almost always after deviation from the recommended postexposure treatment protocol. In two cases with bites to the face, treatment failed although no deviation from the recommended postexposure treatment protocol appeared to have occurred.

The sooner treatment is begun after exposure, the better. However, there have been instances in which the decision to begin treatment was made as late as 6 months or longer after exposure due to delay in recognition that an exposure had occurred. Postexposure antirabies treatment should always include administration of both passive antibody (HRIG) and rabies vaccination series, with the exception of persons who have previously received complete immunization regimens (preexposure or postexposure) with a cell culture vaccine, or persons who have been immunized with other types of vaccines and have had documented rabies antibody titers. Persons who have previously received rabies immunization should receive 2 IM doses of RabAvert: 1 on day 0 and another on day 3. They should not be given HRIG as this may blunt their immune system rapid memory response to rabies vaccine antigen.

Serum rabies antibody should be measured 2-4 weeks (physician decision) after the last vaccine dose.


In view of the almost invariably fatal outcome of rabies, there is no contraindication to postexposure prophylaxis, including pregnancy, where there is legitimate exposure. If there had been prior anaphylactic allergic reaction to HRIG or the vaccine, that would be managed by expert consultation with an Allergy / Immunology specialist, but the rabies preventive treatment is still indicated as soon as possible.

Altered Immune Status

Individuals with diseases which impair or weaken their immune systems (HIV, blood and blood-forming malignancies, lymphomas, etc.) or who have recently received or are on immune-compromising treatments (steroids; cancer chemotherapy; radiotherapy; autoimmune disease biologicals, like Remicaid, Humira, Embrel, etc.) may have suboptimal responses to any vaccine. Such cases must be evaluated individually by an expert to decide if the usual vaccination schedule will be sufficient to provide protection and when post-vaccination protective rabies antibody should be measured to assure the vaccine worked. Immune-suppressant medications may need to be held during rabies immunization and not resumed until an expert has recommended it.

Frequent Rabies Questions / Issues

  1. Bats don’t “carry” rabies. Like other mammals, they must be infected (ill) to be shedding rabies virus, and so are a risk to give it to other animals / humans.
    About 1% of bats are rabid. If a bat is flying around during daytime, enters a house, has contact with humans, or is found lying on a surface, it is more than likely to have rabies.
  2. Only several people die yearly in the U.S. from rabies. A person living in the U.S. is more likely to catch polio, leprosy, or plague.
    Worldwide, over 30,000 die each year – 99% from unvaccinated, rabid dogs and cats.
  3. People can have had bat contact without knowing it and without apparent bite marks. A person who has been  intellectually incompetent (dementia, small kids) or mentally unaware (sleeping, medicated, or intoxicated) for any amount of time in a closed air-space where a bat is found MUST receive full rabies preventive care unless the bat’s brain can be confirmed as rabies negative by testing by Animal Control.
  4. You cannot catch rabies by just being near a bat (unless physical trauma to the bat produces aerosolized blood that lands on human mucous membranes in the eyes, nose, or mouth, or rarely by aerosol exposure in bat caves. Otherwise, there must be direct  physical contact.
  5. There is no evidence that bats transmit rabies to other kinds of wildlife or domestic pets. Numerous carnivores gather to feed on the 20 million Mexican free-tailed bats at Bracken Cave, TX, and there have been no known rabies outbreaks in those animals.
  6. Large urban bat colonies (such as at the famous Congress Avenue Bridge in Austin, TX) have not been linked to increased human rabies cases.
  7. Bat rabies has been implicated in most U.S. human rabies cases the past 25 years.
  8. Media, health agencies, and inexpert physicians who do not regularly deal with rabies exposure, diagnosis, and treatment may give misinformation and inappropriate recommendations. With rabies, you must see an expert for proper advice and care.
  9. Rabies exposure can be avoided by vaccinating domestic pets; avoiding stray/wild animals; not “taking in” sick animals (without Animal Control advice); not handling stray/wild animals (especially bats) or touching carcasses. Any animal bite or contact with a wild/stray animal should be discussed with a physician expert or Animal Control. This includes raccoons and feral cats
  10. Post-exposure rabies treatment is not extremely painful as in the past. Shots are no longer given in the abdomen. They are given in the thigh or upper arm and the experience is the same as with a flu shot.